Testicular Germ Cell Tumors


MalaCards based summary: Testicular Germ Cell Tumor, also known as spermatocytic seminoma, is related to endodermal sinus tumor and childhood endodermal sinus tumor, and has symptoms including cryptorchidism, gonadal dysgenesis and abnormality of metabolism/homeostasis. An important gene associated with Testicular Germ Cell Tumor is STK11 (Serine/Threonine Kinase 11), and among its related pathways are C-MYB transcription factor network and Signaling events mediated by HDAC Class III. Affiliated tissues include brain, t cells and lung, and related mouse phenotypes are Increased cell viability after pRB stimulation and Synthetic lethal with MLN4924 (a NAE inhibitor).

Disease-associated SNP
Dissease-associated Gene
Disease-associated LncRNA
Lncrna ID Location SNP Protein Option
ENST00000469289.1 chr1:30267-31109 - SPRY4
ENST00000442116.1 chr1:257864-264733 - HSD17B1
ENST00000613471.1 chr1:476738-489710 - STK11
ENST00000432964.1 chr1:498281-499175 - AFP, BAX
ENST00000422528.1 chr1:760911-761989 - MIR199A1, UCK2, CDKN1A
ENST00000593022.4 chr1:784370-806459 - TP53, HSD17B1
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Co-expression Network:
If the number of edges is greater than 100k, we provided the graph containing 85k edges.